Targeting Mutational Landscape of TP53 in patients diagnosed with Oral Cancer living in Senegal

Introduction Genomic mutations in TP53 gene association with etiological risk factors have been associated oral carcinogenesis. Herein, we screened for genomic variants of predisposing to cancers Senegalese patients. Methodology 88 patients confirmed diagnostic were recruited after informed consent. Blood samples collected from each patient perform DNA extraction, PCR amplification all coding exons followed by Sanger Sequencing products. Nucleotide sequences analysed Genalys software. 94 blood donors no cancer diagnosis also as controls study between the most common identified and predisposition cancers. Results Sequence analysis showed that 52.27% carry at least one mutation TP53. Eleven identified, 7 already reported databases 4 new variants. The recurrent this cancer-related Pro72Arg (rs1042522; Arginine frequency estimated 31.26%) a 16 bp insertion intron 3 (rs59758982; allelic 26.25%). Haplotype these strong linkage disequilibrium (D’ = 0.999, r2 0.153 p-value < 0.05). However, did not find any significant susceptibility (p-value > Conclusion Our highlighted despite absence two diagnosed cancer, their LD suggested they could be transmitted together haplotype which may implicated